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Journal Article 2

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2021 1

2013 1

Keywords

Chemosensitivity 1

Gemcitabine 1

Intrahepatic cholangiocarcinoma 1

PF-00477736 1

Peripheral blood mononuclear cells 1

cancer stem cell 1

checkpoint kinase 1 (CHK1) 1

drug resistance 1

lung cancer 1

tumorigenicity 1

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Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-like

Douglas D. Fang, Joan Cao, Jitesh P. Jani, Konstantinos Tsaparikos, Alessandra Blasina, Jill Kornmann, Maruja E. Lira, Jianying Wang, Zuzana Jirout, Justin Bingham, Zhou Zhu, Yin Gu, Gerrit Los, Zdenek Hostomsky, Todd VanArsdale

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 462-476 doi: 10.1007/s11684-013-0270-6

Abstract: Treating these CSC-like cells with gemcitabine alone and a combination of gemcitabine and the novel CHK1inhibitor PF-00477736 revealed that PF-00477736 enhances the anti-proliferative effect of gemcitabineHowever, the CSC-like cells exhibited resistance to gemcitabine-induced apoptosis.

Keywords： drug resistance     cancer stem cell     checkpoint kinase 1 (CHK1)     PF-00477736     lung cancer     tumorigenicity    

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Distinct Immune Signatures in Peripheral Blood Predict Chemosensitivity in Intrahepatic Cholangiocarcinoma Patients Article

Tong Wu, Ying-Cheng Yang, Bo Zheng, Xue-Bing Shi, Wei Li, Wen-Cong Ma, Shan Wang, Zhi-Xuan Li, Yan-Jing Zhu, Jian-Min Wu, Kai-Ting Wang, Yan Zhao, Rui Wu, Cheng-Jun Sui, Si-Yun Shen, Xuan Wu, Lei Chen, Zhen-Gang Yuan, Hong-Yang Wang

Engineering 2021, Volume 7, Issue 10,   Pages 1381-1393 doi: 10.1016/j.eng.2021.01.014

Abstract: A total of 20 ICC patients treated with gemcitabine (GEM) were enrolled in our study, including eight

Keywords： Intrahepatic cholangiocarcinoma     Gemcitabine     Chemosensitivity     Peripheral blood mononuclear cells    

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Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-like

Douglas D. Fang, Joan Cao, Jitesh P. Jani, Konstantinos Tsaparikos, Alessandra Blasina, Jill Kornmann, Maruja E. Lira, Jianying Wang, Zuzana Jirout, Justin Bingham, Zhou Zhu, Yin Gu, Gerrit Los, Zdenek Hostomsky, Todd VanArsdale

Journal Article

Distinct Immune Signatures in Peripheral Blood Predict Chemosensitivity in Intrahepatic Cholangiocarcinoma Patients

Tong Wu, Ying-Cheng Yang, Bo Zheng, Xue-Bing Shi, Wei Li, Wen-Cong Ma, Shan Wang, Zhi-Xuan Li, Yan-Jing Zhu, Jian-Min Wu, Kai-Ting Wang, Yan Zhao, Rui Wu, Cheng-Jun Sui, Si-Yun Shen, Xuan Wu, Lei Chen, Zhen-Gang Yuan, Hong-Yang Wang

Journal Article